AIN (Anal Intraepithelial Neoplasia)

Anal Intraepithelial Neoplasia

“Anal Intraepithelial Neoplasia is typically a rare condition for the general population, however certain high-risk groups have a tendency to develop it. Research suggests that AIN is prevalent in the HPV, HIV, and MSM afflicted groups, as well as certain post-organ transplant patients. AIN is on the rise, with a increase of up to 14% in recent years in certain predisposed populations.

For most people, AIN causes no harm and goes away without treatment. However, if it remains in the body, it can cause trouble in the long-run.

AIN Can be divided into three grades.

AIN 1 – the cells lining the anus are slightly abnormal

AIN 2 – the cells are moderately abnormal

AIN 3 – the cells are severely abnormal

Low grade AIN means that the cells are slightly different from normal anal cells and you may not need treatment. Your provider may suggest regular check-ups to ensure that it is going away on its own, and preform a retest at a later date to determine if there was any progression.

Treatment for low grade AIN does exist, and some patients report that treatment can relieve symptoms such as burning, itching and bleeding.

High grade AIN likely needs treatment, such as skin creams, ablation of the cells (using laser or heat), or trichloroacetic acid. Your provider will determine the best course of action for you. Surgery may even be an option to remove the irregular cells.

It is important to note that AIN is not anal cancer. However, these high grade lesions can occasionally develop into anal cancer. Depending on the size and placement of AIN caused anal cancer, there are many different treatment options including surgery and chemotherapy.