Familial Adenomatous Polyposis (FAP)

Familial Adenomatous Polyposis (FAP) is a rare, inherited condition that greatly increases the risk of colorectal cancer. It is caused by a mutation in the APC gene, which normally helps regulate cell growth in the lining of the colon and rectum. When this gene does not function properly, numerous polyps can develop, which often begins in the teenage years. Without treatment, the lifetime risk of colorectal cancer in classic FAP increases drastically.

There are two main forms of FAP, classic and attenuated:

• Classic FAP typically involves hundreds to thousands of polyps and carries a high risk of early-onset cancer.
• Attenuated FAP involves fewer polyps and may present later in life, but still requires careful monitoring and management.

Early diagnosis is critical. Evaluation may include colonoscopy, genetic testing, and assessment of family history. Because FAP is hereditary, family members may also benefit from genetic counseling and screening.

Treatment focuses on cancer prevention. This often involves regular surveillance and, in many cases, preventive colorectal surgery. Even after surgery, lifelong follow-up is suggested to monitor for remaining or related risks.

How Our Clinic Cares for Patients with FAP

Our clinic provides comprehensive, personalized care for individuals and families affected by FAP. We bring together specialists in gastroenterology, colorectal surgery, genetics, and oncology to create individualized care plans tailored to each patient’s needs.

We guide patients through every step; from genetic counseling and screening, to surgical decision-making and long-term follow-up. Our goal is not only to reduce cancer risk, but also to support quality of life through compassionate, coordinated care. Our providers at CSA are committed to help you navigate the journey with FAP.”